DOTA tris(tBu)ester NHS ester

DOTA tris(tBu)ester NHS ester - Names and Identifiers

Name	DOTA-mono-NHS-tris(t-Bu ester)(B-270)
Synonyms	DOTA-tris-tBu-ester NHS DOTA tris(tBu)ester NHS ester DOTA-Mono-NHS-tris(t-Bu ester) DOTA-mono-NHS-tris(t-Bu ester)(B-270) 1,4,7,10-Tetraazacyclododecane-1,4,7-triacetic acid, 10-[2-[(2,5-dioxo-1-pyrrolidinyl)oxy]-2-oxoethyl]-, tris(1,1-diMethylethyl) ester
CAS	819869-77-7

DOTA tris(tBu)ester NHS ester - Physico-chemical Properties

Molecular Formula	C32H55N5O10
Molar Mass	669.81
Density	1.21±0.1 g/cm3(Predicted)
Boling Point	686.8±65.0 °C(Predicted)
pKa	5.49±0.20(Predicted)
Physical and Chemical Properties	Bioactive DOTA-tris(tBu)ester NHS ester is a derivative of DOTA used to label peptides and antibodies.

DOTA tris(tBu)ester NHS ester - Upstream Downstream Industry

Raw Materials	1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetraacetic acid, tris(1,1-diMethylethyl) ethyl ester TRI-T-BUTYL 1 4 7 10-TETRAAZACYCLODODECA TRI-TERT-BUTYL 1 4 7 10-TETRAAZACYCLODOD N-Hydroxysuccinimide
Downstream Products	1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetraacetic acid, 1-(2,5-dioxo-1-pyrrolidinyl) ester

DOTA tris(tBu)ester NHS ester - Introduction

DOTA-mono-NHS-tris(t-Bu ester)(B-270) (DOTA-mono-NHS-tris(t-Bu ester) or simply B- 270) is a compound with the following properties and uses:

Nature:
-chemical name: DOTA-mono-NHS-tris(t-Bu ester)
-Molecular formula: C35H54N4O12
-Molecular weight: 718.82g/mol
-Appearance: White or similar white crystal or powder
-Soluble: Soluble in organic solvents such as dimethyl sulfoxide, dimethyl amide and dichloromethane, insoluble in water

Use:
- DOTA-mono-NHS-Tri-tert-butyl ester is mainly used in the preparation process of drug radionuclide labeling and biological labeling, and is used as a functional group chemical modifier for biological macromolecules such as proteins and polypeptides.
-It can react with amino acid residues (such as lysine, histidine) in protein molecules to form covalent bonds, giving it specific chemical properties or for drug analysis and treatment.

Method:
-The preparation method of DOTA-mono-NHS-Tri-tert-butyl ester is generally obtained by chemical synthesis. The specific steps include reacting the DOTA compound with NHS(N-hydroxysuccinimide), and then using tri-tert-butyl silicon oxide ester (t-Bu-O-Si(OCH3)3) to react to obtain the target product.

Safety Information:
- DOTA-mono-NHS-Tri-tert-butyl ester is usually relatively safe under the premise of correct use.
-However, please note the following safety precautions:
-Due to its chemical reactivity and irritation to skin, eyes and mucous membranes, care should be taken to avoid contact with skin, eyes and mouth. If contact occurs, rinse immediately with clean water and seek medical assistance.
-Avoid contact with flammable substances and oxidants during use and storage.
-If waste needs to be disposed of, it should be disposed of in accordance with the relevant chemical waste management regulations.

when using chemicals in the laboratory, please always pay attention to safe operation and read the relevant chemical Safety Data Sheet (MSDS) for detailed safety information and Operation suggestions.

Last Update：2024-04-09 21:04:16

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